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Multi-target combinatory strategy to overcome tumor immune escape

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 208-215 doi: 10.1007/s11684-022-0922-5

Abstract: The use of several antibody drugs that target PD1/PD-L1 for various cancer treatments has been approved

Keywords： immune checkpoints     multi-target     immune escape     immune-related adverse events     combination therapy    

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Atypical pituitary hormone–target tissue axis

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 1-17 doi: 10.1007/s11684-022-0973-7

Abstract: A long-held belief is that pituitary hormones bind to their cognate receptors in classical target glandshave shown that multiple types of pituitary hormone receptors are widely expressed in non-classical targetgland-derived hormone exhibits a wide range of nonconventional biological effects in these non-classical targetnon-classical organs were summarized, defined by the novel concept of an “atypical pituitary hormone–targetThe continued exploration of the physiology of the “atypical pituitary hormone–target tissue axis” could

Keywords： thyroid-stimulating hormone     follicle-stimulating hormone     luteinizing hormone     adrenocorticotrophic hormone     prolactin    

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Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma

Zhi Xu,Chunxiang Cao,Haiyan Xia,Shujing Shi,Lingzhi Hong,Xiaowei Wei,Dongying Gu,Jianmin Bian,Zijun Liu,Wenbin Huang,Yixin Zhang,Song He,Nikki Pui-Yue Lee,Jinfei Chen

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 52-60 doi: 10.1007/s11684-016-0433-3

Abstract:  Overall, results suggest that PPM1D is a potential prognostic marker and therapeutic target

Keywords： PPM1D     hepatocellular carcinoma     prognosis     target therapy    

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Amodified variable rate particle filter for maneuvering target tracking

Yun-fei GUO,Kong-shuai FAN,Dong-liang PENG,Ji-an LUO,Han SHENTU

Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 11,   Pages 985-994 doi: 10.1631/FITEE.1500149

Abstract: To address the problem of maneuvering target tracking, where the target trajectory has prolonged smoothCompared with conventional variable rate models, the proposed model does not need any prior knowledge of target

Keywords： Maneuvering target tracking     Prolonged smooth regions     Variable rate model     Maneuver detection    

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Lightweight design of an electric bus body structure with analytical target cascading

Frontiers of Mechanical Engineering 2023, Volume 18, Issue 1, doi: 10.1007/s11465-022-0718-y

Abstract: newly developed multi-material electric bus body structure is examined in combination with analytical target

Keywords： electric vehicle     body in white (BIW)     lightweight     analytical target cascading (ATC)    

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Dynamic Target Tracking of Unmanned Aerial Vehicles Under Unpredictable Disturbances

Yanjie Chen,Yangning Wu,Limin Lan,Hang Zhong,Zhiqiang Miao,Hui Zhang,Yaonan Wang,

Engineering doi: 10.1016/j.eng.2023.05.017

Abstract: IBVS) method based on a velocity observer for an unmanned aerial vehicle (UAV) for tracking a dynamic targetthen considers the uncertainties caused by the unpredictable rotations and velocities of the dynamic targetA novel image depth model that extends the IBVS method to track a rotating target with arbitrary orientationsThe depth model ensures image feature accuracy and image trajectory smoothness in rotating target trackingThe relative velocities of the UAV and the dynamic target are estimated using the proposed velocity observer

Keywords： Unmanned aerial vehicle     Visual servoing     Velocity observer     Target tracking    

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A methodology of implementing target mixing ratio for asphalt mixture

Yucheng HUANG, Lun JI, Rui WEN, Ming ZHANG

Frontiers of Structural and Civil Engineering 2017, Volume 11, Issue 3,   Pages 308-314 doi: 10.1007/s11709-017-0405-y

Abstract: In order to implement the objective mix design of hot mix asphalt adequately during the construction process, the significance of objective mixing ratio was elaborated, and the variability of materials and its control method were analyzed. An engineering example is used to illustrate the debugging process of asphalt mixture batching & mixing plant and the dynamic quality management methods. The results show that the set of methods can not only implement the objective mixing ratio of hot mix asphalt adequately, but also control production during the construction process effectively.

Keywords： asphalt mixture     target mixing ratio     mix design implementation     batching & mixing plant debugging    

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Surface Ship Target Recognition Research Based on SGA

Jiang Dingding,Xu Zhaolin,Li Kairui

Strategic Study of CAE 2004, Volume 6, Issue 8,   Pages 79-81

Abstract:

Surface ship recognition is an important contents of navy's aviation probe. This text discussed the principle, characteristics and calculating step of SGA, and applied this calculating way to surface ship recognition. The experiment results proved the scientificalness and the practical applicability of that methoded.

Keywords： SGA     target recognition     surface ship    

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Moving target detection in the cepstrum domain for passive coherent location (PCL) radar

Ji-chuan LI,Xiao-de LU,Hui ZHANG,Peng-cheng YANG,Yu LIU,Mao-sheng XIANG

Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 9,   Pages 785-795 doi: 10.1631/FITEE.1500036

Abstract: A cepstrum moving target detection (CEPMTD) algorithm based on cepstrum techniques is proposed for passiveThe primary cepstrum techniques are of great success in recognizing the arrival times of static targetTheoretical analyses show that only the target’s peak can be coherently added.

Keywords： Moving target detection     Cepstrum techniques     Cross ambiguity function (CAF)     Passive coherent location    

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Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 627-636 doi: 10.1007/s11684-020-0815-4

Abstract: This expression pattern was coordinated by target repression and promoter hypermethylation.Using chromatin immunoprecipitation sequencing data, we found that RUNX1 target genes tended to be repressed

Keywords： RUNX1     gene mutation     acute myeloid leukemia     transcriptional repression     DNA methylation    

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Anovel approach of noise statistics estimate using H∞ filter in target tracking

Xie WANG,Mei-qin LIU,Zhen FAN,Sen-lin ZHANG

Frontiers of Information Technology & Electronic Engineering 2016, Volume 17, Issue 5,   Pages 449-457 doi: 10.1631/FITEE.1500262

Abstract: Noise statistics are essential for estimation performance. In practical situations, however, a priori information of noise statistics is often imperfect. Previous work on noise statistics identification in linear systems still requires initial prior knowledge of the noise. A novel approach is presented in this paper to solve this paradox. First, we apply the H∞ filter to obtain the system state estimates without the common assumptions about the noise in conventional adaptive filters. Then by applying state estimates obtained from the H∞ filter, better estimates of the noise mean and covariance can be achieved, which can improve the performance of estimation. The proposed approach makes the best use of the system knowledge without a priori information with modest computation cost, which makes it possible to be applied online. Finally, numerical examples are presented to show the efficiency of this approach.

Keywords： Noise estimate     H∞     filter     Target tracking    

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Speciation evolutions of target metals (Cd, Pb) influenced by chlorine and sulfur during sewage sludge

Jingde LUAN,Rundong LI,Zhihui ZHANG,Yanlong LI,Yun ZHAO

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 6,   Pages 871-876 doi: 10.1007/s11783-013-0621-1

Abstract: In sludge incineration, the thermal behavior of heavy metal is a growing concern. In this work, the combined analysis of metal partitioning behavior between vapor phase and condensed phase, speciation redistribution in condensed phase and the difference of metal species in binding energy was carried out to investigate the possible volatilization-condensation mechanism of heavy metals in high-temperature sludge incineration. It was found that there were two steps in metal volatilization. The initial volatilization of heavy metal originated from their exchangeable (EXC), carbonate bound (CAR) and iron–manganese bound (FM) fractions, which is primarily composed of simple substance, chlorides, oxides and sulfides. With the increase of chlorine and sulfur in sludge, the inner speciation redistribution of heavy metals occurred in condensed phase, which was an important factor affecting the potential volatility of heavy metals. A partial of metal species with complexed (COM) and residual (RES) fractions gradually decomposed into simple substance or ions, oxides and carbonates, which significantly strengthened the second volatility. In presence of chlorine, about 46% of Cd with the RES fraction disappeared when the volatility rate of Cd increased by 44.89%. Moreover, about 9% of Pb with COM fraction disappeared when there was an increase of nearly 10% in the volatilization rate. Thus, the second volatilization was mainly controlled by the decomposition of metal species with COM and RES fractions. By virtue of XRD analysis and the binding energy calculation, it was found that metal complex and silicates were inclined to decompose under high temperature due to poor thermo stability as compared with sulfates.

Keywords： sludge incineration     heavy metals     inner speciation redistribution     binding energy    

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support and metal oxide nanoparticles in hybrid nanosorbent materials (HNMs) for sorption/desorption of target

Ryan C. SMITH,Jinze LI,Surapol PADUNGTHON,Arup K. SENGUPTA

Frontiers of Environmental Science & Engineering 2015, Volume 9, Issue 5,   Pages 929-938 doi: 10.1007/s11783-015-0795-9

Abstract: Metal oxide nanoparticles like hydrated ferric oxide (HFO) or hydrated zirconium oxide (HZrO) are excellent sorbents for environmentally significant ligands like phosphate, arsenic, or fluoride, present at trace concentrations. Since the sorption capacity is surface dependent for HFO and HZrO, nanoscale sizes offer significant enhancement in performance. However, due to their miniscule sizes, low attrition resistance, and poor durability they are unable to be used in typical plug-flow column setups. Meanwhile ion exchange resins, which have no specific affinity toward anionic ligands, are durable and chemically stable. By impregnating metal oxide nanoparticles inside a polymer support, with or without functional groups, a hybrid nanosorbent material (HNM) can be prepared. A HNM is durable, mechanically strong, and chemically stable. The functional groups of the polymeric support will affect the overall removal efficiency of the ligands exerted by the Donnan Membrane Effect. For example, the removal of arsenic by HFO or the removal of fluoride by HZrO is enhanced by using anion exchange resins. The HNM can be precisely tuned to remove one type of contaminant over another type. Also, the physical morphology of the support material, spherical bead versus ion exchange fiber, has a significant effect on kinetics of sorption and desorption. HNMs also possess dual sorption sites and are capable of removing multiple contaminants, namely, arsenate and perchlorate, concurrently.

Keywords： ion exchange     sorption     arsenic     perchlorate     fluoride    

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Multi-UAV cooperative target tracking with bounded noise for connectivity preservation

Rui Zhou, Yu Feng, Bin Di, Jiang Zhao, Yan Hu,jzhao@buaa.edu.cn

Frontiers of Information Technology & Electronic Engineering 2020, Volume 21, Issue 10,   Pages 1413-1534 doi: 10.1631/FITEE.1900617

Abstract: We investigate cooperative target tracking of multiple unmanned aerial vehicles (UAVs) with a limitedThis is an integration of UAV motion control, target state estimation, and network topology control.By taking stable target tracking into account, a distributed potential function based UAV motion controllerSince only the estimation of the target state rather than the state itself is available for UAV motionmotion can also affect the accuracy of state estimation, it is clear that the UAV motion control and target
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Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases

Chong Liu, Dingfeng Su

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 35-40 doi: 10.1007/s11684-012-0171-0

Abstract:

Inflammation is important in the pathogenesis and development of cardiovascular diseases. Recent studies show that vagus nerve stimulation inhibits pro-inflammatory cytokine production through “the cholinergic anti-inflammatory pathway,” more specifically via the α7 nicotinic acetylcholine receptor (α7nAChR). In the current study, the role of the cholinergic anti-inflammatory pathway during septic shock, hypertension, and myocardial infarction is reviewed, and its possible clinical implications in cardiovascular diseases are discussed.

Keywords： α7 nicotinic acetylcholine receptor     cardiovascular diseases     baroreflex sensitivity    

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Title Author Date Type Operation

Multi-target combinatory strategy to overcome tumor immune escape

Journal Article

Atypical pituitary hormone–target tissue axis

Journal Article

Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma

Zhi Xu,Chunxiang Cao,Haiyan Xia,Shujing Shi,Lingzhi Hong,Xiaowei Wei,Dongying Gu,Jianmin Bian,Zijun Liu,Wenbin Huang,Yixin Zhang,Song He,Nikki Pui-Yue Lee,Jinfei Chen

Journal Article

Amodified variable rate particle filter for maneuvering target tracking

Yun-fei GUO,Kong-shuai FAN,Dong-liang PENG,Ji-an LUO,Han SHENTU

Journal Article

Lightweight design of an electric bus body structure with analytical target cascading

Journal Article

Dynamic Target Tracking of Unmanned Aerial Vehicles Under Unpredictable Disturbances

Yanjie Chen,Yangning Wu,Limin Lan,Hang Zhong,Zhiqiang Miao,Hui Zhang,Yaonan Wang,

Journal Article

A methodology of implementing target mixing ratio for asphalt mixture

Yucheng HUANG, Lun JI, Rui WEN, Ming ZHANG

Journal Article

Surface Ship Target Recognition Research Based on SGA

Jiang Dingding,Xu Zhaolin,Li Kairui

Journal Article

Moving target detection in the cepstrum domain for passive coherent location (PCL) radar

Ji-chuan LI,Xiao-de LU,Hui ZHANG,Peng-cheng YANG,Yu LIU,Mao-sheng XIANG

Journal Article

Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Journal Article

Anovel approach of noise statistics estimate using H∞ filter in target tracking

Xie WANG,Mei-qin LIU,Zhen FAN,Sen-lin ZHANG

Journal Article

Speciation evolutions of target metals (Cd, Pb) influenced by chlorine and sulfur during sewage sludge

Jingde LUAN,Rundong LI,Zhihui ZHANG,Yanlong LI,Yun ZHAO

Journal Article

support and metal oxide nanoparticles in hybrid nanosorbent materials (HNMs) for sorption/desorption of target

Ryan C. SMITH,Jinze LI,Surapol PADUNGTHON,Arup K. SENGUPTA

Journal Article

Multi-UAV cooperative target tracking with bounded noise for connectivity preservation

Rui Zhou, Yu Feng, Bin Di, Jiang Zhao, Yan Hu,jzhao@buaa.edu.cn

Journal Article

Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases

Chong Liu, Dingfeng Su

Journal Article